|
KMID : 1146920200500030231
|
|
Journal of Pharmaceutical Investigation
2020 Volume.50 No. 3 p.231 ~ p.250
|
|
|
Application of diethylene glycol monoethyl ether in solubilization of poorly water-soluble drugs
|
|
Ha Eun-Sol
Lee Seon-Kwang
Choi Du-Hyung
Jeong Seong-Hoon
Hwang Sung-Joo
Kim Min-Soo
|
|
|
Abstract
|
|
|
Background: Diethylene glycol monoethyl ether (DEGEE) is produced via the O-alkylation of ethanol with two ethylene oxide units, followed by distillation. It has a long history of safe use in food and personal-care products, and is used as an effective strong solubilizer in oral, topical, transdermal, and injectable human and veterinary pharmaceutical products. It has been used as a pharmaceutical solvent for many years under the trade name transcutol. DEGEE, a hydroalcoholic solvent, is gaining interest as a penetration/permeation enhancer, solubilizer, and surfactant for drug delivery systems.
Area covered: The physicochemical properties of DEGEE, the solubility data for drugs in DEGEE or DEGEE-water mixtures, and the applications of DEGEE in the solubilization of poorly water-soluble drugs are summarized in this review.
Expert opinion: DEGEE is a promising excipient as a solubilizer for many pharmaceutical products with enhanced drug absorption via oral, parenteral, and topical administration, as well as cosmetic products.
|
|
|
KEYWORD
|
|
|
Diethylene glycol monoethyl ether, Solubilizer, Solubility, Cosolvent, Transcutol
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
|
|